Predictive modelling is vital to guide preventive efforts. Whilst large-scale prospective cohort studies and a diverse toolkit of available machine learning (ML) algorithms have facilitated such survival task efforts, choosing the best-performing algorithm remains challenging. Benchmarking studies to date focus on relatively small-scale datasets and it is unclear how well such findings translate to large datasets that combine omics and clinical features. We sought to benchmark eight distinct survival task implementations, ranging from linear to deep learning (DL) models, within the large-scale prospective cohort study UK Biobank (UKB). We compared discrimination and computational requirements across heterogenous predictor matrices and endpoints. Finally, we assessed how well different architectures scale with sample sizes ranging from n = 5,000 to n = 250,000 individuals. Our results show that discriminative performance across a multitude of metrices is dependent on endpoint frequency and predictor matrix properties, with very robust performance of (penalised) COX Proportional Hazards (COX-PH) models. Of note, there are certain scenarios which favour more complex frameworks, specifically if working with larger numbers of observations and relatively simple predictor matrices. The observed computational requirements were vastly different, and we provide solutions in cases where current implementations were impracticable. In conclusion, this work delineates how optimal model choice is dependent on a variety of factors, including sample size, endpoint frequency and predictor matrix properties, thus constituting an informative resource for researchers working on similar datasets. Furthermore, we showcase how linear models still display a highly effective and scalable platform to perform risk modelling at scale and suggest that those are reported alongside non-linear ML models.

Accurate wind speed prediction is crucial for designing and selecting sites for offshore wind farms. This paper investigates the effectiveness of various machine learning models in predicting offshore wind power for a site near the Gulf of Mexico by analyzing meteorological data. After collecting and preprocessing meteorological data, nine different input feature combinations were designed to assess their impact on wind power predictions at multiple heights. The results show that using wind speed as the output feature improves prediction accuracy by approximately 10% compared to using wind power as the output. In addition, the improvement of multi-feature input compared with single-feature input is not obvious mainly due to the poor correlation among key features and limited generalization ability of models. These findings underscore the importance of selecting appropriate output features and highlight considerations for using machine learning in wind power forecasting, offering insights that could guide future wind power prediction models and conversion techniques.